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Vinpocetine

One thing almost everyone knows is that dietary supplement ingredients need to be all natural, except when you’re talking about vinpocetine. Despite the FDA making it clear it does not believe vinpocetine to be a legal dietary supplement ingredient[1], it doesn’t appear to be breaking down the doors of companies who still choose to include it in supplements.

With this lapse of enforcement by the FDA, one may want to try vinpocetine to see how it stacks up against other nootropics now while they still can.

What it does

Vinpocetine is a pretty impressive nootropic that has the benefit of extreme human testing to prove its merits. It has been shown to increase memory formation and reaction times[2], reduce cognitive decline[3], and increase the relative well-being of users[4].

How it works

Vinpocetine is a phosphodiesterase type-1 inhibitor[5], which may allow it to enhance levels of secondary messengers cAMP/cGMP, ultimately leading to a greater expression of neuronal plasticity-related genes and neuroprotective molecules[6].

Although unsupported currently by human research, theories exist which claim it may exert some of its nootropic effects via increases of blood flow within the blood.

Dosing

Suggested dosing on vinpocetine is 15-30mg per day, taken in 1-3 doses. For most intense nootropic effects, this can be taken in a single bolus dose 30-45 minutes before exercise. For daily brain enhancement, the best dosing strategy is 5-10mg taken over three individual doses.

References

  1. https://www.fda.gov/Food/DietarySupplements/ProductsIngredients/ucm518478.htm
  2. https://www.ncbi.nlm.nih.gov/pubmed/3899677
  3. https://www.ncbi.nlm.nih.gov/pubmed/21311488
  4. https://www.ncbi.nlm.nih.gov/pubmed/21183904
  5. https://www.ncbi.nlm.nih.gov/pubmed/6322804
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044262/