HydroNOx is a promising pre-workout innovation from Vireo, the same company behind CON-CRET creatine HCl. It uses a citrulline HCl structure to deliver a more concentrated, highly soluble, and bioavailable version of the classic pump ingredient. Like CON-CRET, HydroNOx is designed to provide superior efficiency in a smaller dose, with early callouts saying that 2g may match or exceed the effects of 6g of regular citrulline.
Ahead of the release of its clinical study, Vireo has shared highlights from that showing HydroNOx outperforms citrulline in several key areas. It achieved 333% better citrulline-to-arginine conversion, 1.7x higher peak arginine levels, and a 50–100% faster absorption rate. The study also found it reached peak arginine concentrations twice as fast and offered three times the solubility, supporting significantly greater efficacy per gram.
MuscleTech was one of the first major brands to put HydroNOx to work in the pre-workout category in, featuring it at 2g in its newly launched Stacked Pre, available now at The Vitamin Shoppe. The highlights from the upcoming clinical study are proof as to why MuscleTech made quick use of it. For any brands interested in formulating with HydroNOx, whether it’s one ingredient or the main focus, reach out through Vireo’s website.
