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There’s a certain reality about dietary supplements that is both amazing and frustrating at the same time. It’s the fact that dietary supplements don’t need billions of dollars of research or FDA approval before they’re released for consumer use. This is incredible as it allows consumers to try new and exciting ingredients much faster, but it also means that a vast amount of ingredients come with little to no human data backing their efficacy.

Evodiamine, one of the active constituents found in the evodia rutaecarpa plant is a great example of this. While animal models suggest incredible benefits, the jury is still out on its potential effects in humans.

What it does

Assuming the animal models hold true in future human studies, evodiamine increases fat loss through thermogenesis and increased caloric burn, similar to many other stimulants which are widely available on the market[1][2].

How it works

Evodiamine is classified as a stimulant due to its ability to increase catecholamine (such as epinepdrine, norepinephrine, and dopamine) secretion. Catecholamines increase things such as heart rate, blood pressure, and provide a general reaction to the nervous system, causing users to have more energy and feel more alert.

Unlike other commonly used stimulants, evodiamine features the unique benefit of being able to activate the vanilloid receptor (similarly to capsaicin), which can directly increase thermogenesis and help us burn more calories throughout the day[3].


Due to the lack of human studies on this compound, there is no true “suggested” dosing on evodiamine. Anecdotal reports suggest doses of 50-200mg per serving approximately 30-45 minutes before the desired effects.