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Also known as n,n-dimethyltyramine, hordenine is a naturally occurring compound found in different plants including things like bitter orange (citrus aurantium) and even barley grass. It is chemically related to the phenethylamine family of compounds and shares some similar benefits.

Hordenine is most commonly in weight loss formulas; however, it has been gaining steam in the nootropic category as of late.

What it does

The primary use of hordenine is for its benefits in enhancing weight loss. There is extremely little human data on hordenine, so it’s suggested mechanism of action is proposed by comparing it to similar molecules with more established human pharmacology data.

Hordenine should increase the body’s basal metabolic rate, via increases of fat burning hormones such as norepinephrine, dopamine, and adrenaline. By increasing total caloric expenditure throughout the day, hordenine should allow users to experience enhanced weight loss more than they would without it.

How it works

Hordenine is theorized to raise norepinephrine and dopamine levels via monamine oxidase (MAO) inhibition[1]. MAO is tasked at eliminating norepinephrine, adrenaline, and dopamine, so by inhibiting this enzyme, it makes it possible for the body to experience significantly increased levels.

Studies have indicated that horendine may be capable of acting as a noradrenaline reuptake inhibitor[2], allowing noradrenaline levels to rise as well.


Hordenine dosing protocols vary widely depending on the source. A safe starting point is 25mg 1-3x per day. More experienced users can opt for larger doses, of 50-200mg.