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With the FDA closing in around the dietary supplement industry resulting in fewer and fewer stimulants being available for energy and weight loss, supplement companies are being required to get seriously creative with new ingredients. Isopropylnorsynephrine is a direct result of the dwindling legal stimulant availability, and will more than likely begin to pop up in more and more dietary supplements as time goes on.

What it does

Isopropylnorsynephrine accomplishes what its cousin, synephrine, has always claimed to do, and that is increase lipolysis or fat loss[1]. While synephrine is far more commonly seen and discussed, it has been shown to be only marginally effective at producing weight loss, while isoproylnorsynephrine was found to be “clearly lipolytic” in the aforementioned study.

Although no studies currently exist in regards to the stimulatory potential of this compound, anecdotal reports have shown it to be an extremely strong option for increasing energy in users.

How it works

Isopropylnorsynephrine proved to be lipolytic as it was capable of breaking down lipids (fats) and triglycerides into glycerol and free fatty acids. Once these are broken down, the body is capable of using them as energy/fuel, resulting in body fat stores being “burned”.

For its stimulatory benefits, isopropylnorsynephrine more than likely works through similar mechanisms as synephrine itself, agonizing beta receptors and antagonizing alpha-adrenergic receptors.


Due to the extremely limited data on this compound, specific dosing suggestions are not currently available. Anecdotal reports, however, suggest a dose of only 10mg will provide significant energy and stimulation.

Taking anecdotal reports into consideration, dosing recommendations would be to assess tolerance at 5mg. Once tolerance has been assessed, doses of 10mg per serving would be suggested, with maximum doses being 20mg to potentially 30mg for the most experienced stimulant users.