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TeaCrine® is a patent-pending energy and focus ingredient naturally found in the kucha tea leaf and cupuaçu fruit. It shares molecular similarities with caffeine, yet subtle, significant differences that support energy without jitters, crash or habituation. When used in combination with caffeine, TeaCrine® and caffeine generate a “cleaner” feeling of energy that can last for hours.

What it does

Over a 3-hour period, two human clinical pilot trials with healthy participants showed a statistically significant increase in energy without jitters, irritability, or habituation, increase in motivation to exercise, decrease in feelings of fatigue, and increase in mental energy.

Additionally, TeaCrine® has Informed-Sport and Informed-Choice certifications so competitive athletes can use it with peace of mind. TeaCrine® also has long-term safety data in both humans and rats, an established research program with further clinical trials underway, and multiple patents pending globally through the USPTO and PCT (Patent Cooperation Treaty).

How it works

While caffeine works by inhibiting adenosine receptors, TeaCrine® works by inhibiting adenosine and activating dopamine receptors. Decades of scientific studies show that high dopamine levels result in perceived feelings of energy, improved mood, sensations of pleasure, increased motivation and greater mental focus and clarity.


In isolation, the optimal TeaCrine dose is 200mg. In combination with caffeine, the optimal dose is 125mg.

In a recent Rutgers University study soon to be published, 125mg of TeaCrine in combination with 150mg of caffeine was found to be superior to 275mg of caffeine alone. Anecdotally, however, 75-125mg of TeaCrine is found to be incredible to potentiate energy, mood and focus in combination with 150-400mg of caffeine, or even adaptogens or choline derivatives.


  1. Ziegenfuss et al. A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters. Journal of Dietary Supplements. May 2016.
  2. Taylor et al. Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over weeks of continuous use. Journal of the International Society of Sports Nutrition. 2016.
  3. Kuhman et al. Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women. Nutrients. June 2015.

This information was put together with the help of the creator of TeaCrine, Compound Solutions.