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Synephrine

Synephrine has been a widely used weight loss and energy enhancer since it’s cousin ephedrine was removed from the market. Found in citrus aurantium, synephrine is one of the most commonly used stimulants in weight loss aids today.

What it does

Synephrine has been shown to increase total caloric expenditure[1], allow for an increase number of repetitions[2], and provide a potential anabolic action via gluconogenesis[3].

How it works

Synephrine is an alkaloid and amine that can be produced endogenously in the human body but is often found in high amounts in plants such as the bitter orange or citrus aurantium.

Synephrine exerts its weight loss benefits via increasing lipolysis and basal metabolic rate[4]. It accomplishes these feats thanks to working through similar mechanisms as ephedrine[5], where it acts as a beta-agonist.

Synephrine also antagonizes the alpha-adrenergic receptors, antagonizing both the A1 and A2 receptors[6].

Dosing

Suggested synephrine dosing has not changed much since its release, with daily dosing ranging from 25-75mg. For standard weight loss dosing, 25-35mg taken 1-3x/day is suggested. Single bolus doses of 50-75mg/serving can be taken for more intense effects.

References

  1. http://www.medsci.org/v08p0295.htm
  2. https://www.ncbi.nlm.nih.gov/pubmed/26388707
  3. https://www.ncbi.nlm.nih.gov/pubmed/24287564
  4. https://www.ncbi.nlm.nih.gov/pubmed/16436104
  5. https://www.ncbi.nlm.nih.gov/pubmed/2890747
  6. https://www.ncbi.nlm.nih.gov/pubmed/2833972